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KMID : 0861020080230020225
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Korea Journal of Herbology
2008 Volume.23 No. 2 p.225 ~ p.233
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Neuroprotective Effect of the Roots of Polygonum Cuspidatum on Transient Focal Cerebral Ischemia in Rats
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Kim Jin-Mo
Kim Ho-Cheol
Lim Jong-Pil
Jeon Hoon
Leem Kang-Hyun
Kim Mi-Yeon
Bu Young-Min
Cha Dong-suk
Jeon So-ra
Cui Xun
Lee Ki-Jin
Kang Min-seok
Na Ho-jeong
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Abstract
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Objectives: The purpose of the present study was to development of neuroprotective antioxidant agents. For the purpose, we investigated the neuroprotective effect of anti oxidant herb, the root of Polygonum cuspidatum on transient focal cerebral ischemia in rats.
Methods: The roots of Polygonum cuspidatum were extracted by 85% MeOH (PCE). Radical scavenging effects were investigated using DPPH assay and TBARs (Thiobarbituric acid reaction substance) assay in brian homogenates. Neuroprotective effect was investigated using transient focal cerebral ischemia rat model (2 h of ischemia, 22 h of reperfusion) by behavioral test and measurement of brain damage using 2, 3, 5-triphenyltetrazolium chloride staining.
Results: PCE showed potent and dose dependent radical scavenging effects in DPPH and TBARs assay. Oral administration of PCE reduced brain infarct volume by 29.7% and improved the sensory motor functional deficit by 29% compared with vehicle treated group.
Conclusions: PCE showed radical scavenging effects and neuroprotective effect on stroke rat model. Therefore, Polygonum cuspidatum could be a candidate for the development of neuroprotectiveantioxidant agents.
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KEYWORD
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Polygonum cuspidatum, Radical scavenging effect, Neuroprotection, Middle cerebral artery occlusion, Stroke
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